Skeletal Biology


Skeletal Biology Group


 A skeletal biology group focuses on the cell lineages of osteoblasts and osteoclasts and works on mesenchymal stem cell biology of the skeletal system. Dysregulation of these two cell lineages underlies the pathogenesis of many human skeletal disorders, such as osteoporosis, rheumatoid arthritis and Paget's disease. By utilizing knowledge of certain pathways that are important mediators in the immune system — a novel adaptor protein Schnurri-3 and pathways of the MAPK (mitogen activated protein kinase), the PI3K (phosphoinositide 3-Kinase), and the NF-κB (nuclear factor-kapaB), they seek to uncover the next generation of targeted therapeutics for the treatment of skeletal disorders. Additionally, we have complimented these approaches with large scale screens and have identified new proteins that control osteoblast and osteoclast commitment and activation in skeletal biology.

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1300 York Ave, E-907
NewYork, NY  10065

Phone: 212-746-9661
Fax: 212-746-9215


Dean Glimcher's Lab